ÖZET
Amaç:
Sol ventrikül ejeksiyon fraksiyonu (EF) (LVEF) >%35 ve tek damar tıkanıklığı olan ve primer perkütan koroner girişim (pPCI) ile tedavi edilen ST segment elevasyonlu miyokart enfarktüsü (MI) (STEMI) hastalarında, Galektin-3 (Gal-3) düzeyleri ile mikrovolt T dalga alternans (MTWA) ve sık prematüre ventriküler kompleksler (PVC) arasındaki ilişkiyi belirlemeyi amaçladık.
Gereç ve Yöntem:
Bu kesitsel çalışmaya toplam 81 hasta dahil edildi. Başvuru anında tüm has talardan Gal-3 düzeyleri için kan örnekleri alındı. Hastalar düşük ve yüksek Gal-3 (sırasıyla ≤ ve > 1,93 ng/dL) gruplarına ayrıldı. Düşük Gal-3 ve yüksek Gal-3 grupları hem MTWA hem de PVC pozitifliği açısından karşılaştırılmış ve Gal-3 düzeyleri ile ilişkisi incelenmiştir.
Bulgular:
Düşük Gal-3 grubu ile karşılaştırıldığında, yüksek Gal-3 hastalarında sol atriyal hacim (LAV) daha yüksekti (55,7±18,0’a karşı 40,6±13,7 mL, p<0,001). Çok değişkenli analizler yaş, LAV ve Gal-3 düzeylerinin PVC pozitifliğinin anlamlı bağımsız prediktörleri olduğunu (sırasıyla p=0,005, p=0,04, p=0,002); ve Gal-3’ün, MTWA pozitifliğinin anlamlı bir bağımsız prediktörü olduğunu gösterdi (p=0,002).
Sonuç:
Gal-3, PVC ve MTWA pozitifliği ile ilişkiliydi ve LVEF >%35 olan tek damarlı STE-MI hastalarında aritmik olayların bir prediktörü idi.
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