ÖZET

Amaç:

İnterlökin-33 (IL-33); IL-1 süper ailesine ait yeni bir sitokindir. Ailevi Akdeniz Ateşi (FMF) patogenezinde yer alan IL-1β ile benzer yapısal ve sinyalizasyon yolağına sahiptir. Bu çalışmada, FMF hastalarının serumlarında IL-33 ve bunun reseptörü olan sST2 reseptör seviyelerinin ve hastalık aktivitesi ile ilişkisinin incelenmesi amaçlanmıştır.

Gereç ve Yöntem:

Tek merkezli kesitsel olan bu çalışmaya, 18 yaş ve üzeri 76 FMF hastası ile yaş ve cinsiyet uyumlu 30 sağlıklı bireyler dahil edildi. Hastalık aktivitesi oto-enflamatuvar hastalık aktivite indeksi skoru kullanılarak değerlendirilmiş olup ≥9 puan aktif hastalık olarak kabul edildi. Serum IL-33 ve sST2 seviyeleri enzyme-linked immunosrobent assay kullanılarak çalışıldı. P-değeri <0,05 istatistiksel olarak anlamlı kabul edildi.

Bulgular:

Serum IL-33 ve sST2 değerleri, FMF hastaları ve sağlıklı kontrol grubunda benzer bulundu [sırasıyla (p=0,899 ve p=0,614)]. Aktif (n=24) ve inaktif (n=52) FMF hastaları arasında da serum IL-33 ve sST2 değerleri arasında fark bulunamadı. Ancak, aktif FMF hastalarında serum C-reaktif protein ve serum amiloid A düzeylerinin inaktif hastalara göre istatistiksel olarak anlamlı bir şekilde daha yüksek olduğu görüldü (sırasıyla, p=0,001 ve p=0,002).

Sonuç:

Bu çalışmada, her ne kadar IL-33, IL-1β ile benzer yapıya ve sinyalizasyon yolağına sahip olsa da FMF hastalarında serum düzeylerinin artmadığı ve hastalık aktivitesi ile de ilişkili olmadığı gösterilmiştir. Otoimmün hastalıklarla yapılan çalışmaların aksine, IL33/sST2 yolağının oto-enflamatuvar hastalıklardaki rolünün ileri çalışmalarla incelenmesi gerekmektedir.

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Ailevi Akdeniz Ateşi Patogenezinde IL33/sST2 Yolağı Rol Oynamakta mıdır?

ÖZET

References