ABSTRACT
Objectives:
We aimed to investigate the relationship between iron deficiency without anemia and thiol disulphide homeostasis, which effected oxidative status.
Materials and Methods:
A total of 71 cases, including the 5-15 age group with iron deficiency (n=35) and age- and gender-matched healthy control group (n=36), who applied to the pediatric outpatient clinic, were enrolled in the study. The diagnosis of iron deficiency was established for the patients who had normal hemoglobin levels considering age and gender, and whose ferritin value was <12 ng/mL.
Results:
Ferritin levels were 11.01±0.89 ng/mL in patients with iron deficiency and 25.27±2.57 ng/mL in healthy controls (p<0.001). In patients with iron deficiency, native thiol and total thiol levels were significantly lower (p<0.001 and p<0.001, respectively), and disulphide, disulphide/native thiol ratio and disulphide/total thiol ratio were significantly higher (p<0.001, p<0.001 and p<0.001, respectively). Only total thiol levels had positive correlation with ferritin levels (r=0.330, p=0.049).
Conclusion:
In this study, we showed that iron deficiency has effect on oxidative stress.
Keywords: Iron Deficiency, Oxidative Stress, Thiol Disulphide Homeostasis
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