ÖZET
Amaç:
Genç bireylerde koroner arter hastalığı nispeten nadir görülür. Literatürde genç yaşta koroner arter hastalığı ile ilgili sınırlı veri mevcuttur. Bu çalışmada yeni tanı almış prematür koroner arter hastalığı olanlarda repolarizasyon parametreleri değerlendirildi.
Gereç ve Yöntem:
Çalışmaya toplam 200 hasta [128 erkek, 38,0 (29,3-42,0) yaş] dahil edildi ve bunlardan 100’ü yeni tanı prematür koroner arter hastalığı (yaş ≤45) olan çalışma grubunu oluşturdu. Kalan 100 hasta iyi eşleştirilmiş kontrol grubunu oluşturdu. İki grup arasında DII, V2 ve V6 derivasyonlarında ölçülen, QTc intervali, Tp-e intervali ve Tp-e∕QTc den oluşan repolarizasyon parametreleri karşılaştırıldı.
Bulgular:
Median QTc intervali D2 derivasyonunda (430,3 ms ve 405,3 ms, p<0,001),V2 derivasyonunda (433,8 ms ve 404,7 ms, p<0,001) V6 derivasyonunda (430,2 ms ve 401,7 ms, p<0,001); median Tp-e intervali D2 derivasyonunda (80 ms ve 64 ms, p<0,001), V2 derivasyonunda (82 ms ve 74 ms, p<0,001), V6 derivasyonunda (88 ms ve 72 ms, p<0,001); ve median Tp-e/QTc oranı; D2 derivasyonunda (0,188 ve 0,158, p<0,001), V2 derivasyonunda (0,190 ve 0,181, p=0,022) ve V6 derivasyonunda (0,196 ve 0,183, p<0,001) olmak üzere sırasıyla prematür koroner arter hastalığı olanlarda kontrol grubuna göre anlamlı olarak daha yüksek saptandı.
Sonuç:
Sonuç olarak, prematür koroner arter hastalığı anormal repolarizasyon dispersiyonu ve dolayısıyla aritmik risk ile ilişkili olabilir.
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