ÖZET
Amaç:
Sistemik enflamasyonun bir göstergesi olan nötrofil-lenfosit oranı (NLR) ve ortalama trombosit hacmi (MPV) birçok çalışmada karsinogenez ile ilişkili bulunmuştur. Bu çalışmanın amaç bu iki parametrenin tiroit malignitesini saptamadaki prediktif değerlerini araştırmaktı.
Gereç ve Yöntem:
Üçüncü basamak bir sağlık kuruluşunda Ocak 2010 ile Aralık 2017 tarihleri arasında tiroit ince iğne aspirasyon biyopsisi (İİAB) sonucu önemi belirsiz atipi, foliküler neoplazi, kuşkulu sitoloji raporlanan ve bu nedenle total tiroidektomi ya da hemitiroidektomi uygulanan hastaların incelendi. 225 hastanın verileri retrospektif olarak tarandı ve 144 hasta (29 kadın/115 erkek) çalışmaya dahil edildi.
Bulgular:
Preoperatif NLR değerleri kesin patoloji sonucu malign gelen hastalar ile benign gelenler arasında kıyas yapıldığında malign olanlarda istatistiksel olarak anlamlı saptandı (p=0,002). Preoperatif MPV değerleri ise istatistiksel olarak anlamsız bulundu. İİAB guruplarına göre kıyas yapıldığında ise sadece kuşkulu sitolojide anlamlılık saptadık (p=0,001), diğer guruplarda anlamlılık saptamadık.
Sonuç:
NLR benign ve malign hastalık ayrımında faydalı olabilmektedir fakat İİAB gurupları arasında maligniteyi öngörmede bize hala net bir veri sunamamaktadır.
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