ABSTRACT

In the first part of this review, we described that plaques that we see on MRI are not all the same, there are different plaque patterns between patients and although we cannot detect with conventional MRI, there are cortical plaques in almost all of the patients. In the second part, we will first concentrate on the first phase of disease. We will explain the data that we learned by in vivo imaging of animal models. Thereafter, we will review what we have learned from conventional and non-conventional MRI imaging, and discuss the shortcomings of these methods. After the completion of this section, we hope that readers will have knowledge on the mechanisms of some of the most widely used therapeutic agents and will be able to interpret MR images of MS patients more efficiently.