ABSTRACT

Treatment of severe chronic autoimmune urticaria is difficult. In this study we aimed to investigate efficacy and safety of cyclosporine in patients with chronic urticaria.

Twenty patients with chronic spontaneous urticaria whom detailed physical exami-nation were noted and were treated in our center between 2005 and 2013 were included in this study.

A total 20 patients were included in this study. Daily wheal number and number of angioedema at-tacks had been compared and significant reduce in both parameters were detected. Total duration of treat-ment was mean (min: 4, max: 144) 27,05 (±30,9507 SD, median 18) weeks. Daily cyclosporine dosages were (min: 0,54, max: 3,57), mean 2,2672 (±0,81441SD, median 2,1237). Mild hypertension was detected in two pati-ents under treatment and had been treated with anti hypertensive agents. Dyplopia was developed in 1 pati-ent. We observed elevated creatinine levels in 3 patients.

A daily mean dosage of 2,2672 mg of cyclosporine is effective in treatment of chronic urticaria for a duration of 27 weeks. All patients must be followed up closely to monitore adverse events. Recurrence was seen in a mean 9 weeks after cessation of therapy.

Keywords: Chronic Urticaria, Cyclosporine