Research Article

Comparison of the Effects of Bare Metal Stents and Drug Eluting Stents on C-Reactive Protein Levels


  • Nil Özyüncü
  • Hasan Sadi Güleç
  • Özgür Ulaş Özcan
  • Hüseyin Göksülük
  • Demet Menekşe Gerede Uludağ
  • Çetin Erol

Received Date: 04.08.2020 Accepted Date: 24.08.2020 J Ankara Univ Fac Med 2020;73(3):208-215


It is suggested that drug eluting stents (DES) may have systemic anti-inflammatory properties and this can play a role in decreased restenosis rates. We aimed to compare bare metal stents (BMS) and DES for their effects on C-reactive protein (CRP) levels, a good marker of systemic inflammation. We also aimed to investigate the relationship between the inflammation levels and myonecrosis and adverse cardiac events.

Materials and Methods:

Patients undergoing elective stent implantation were grouped as BMS (n=70) and DES (n=42). Basal and 24th hour postprocedural CRP and creatine kinase-MB (CK-MB) levels were measured and the difference (delta=Δ) was compared between the groups. The patients were followed up for adverse cardiac events for one year.


The mean age was 62±11 years and 75% were males. There was significant CRP rise in both groups at the 24th hour, but the ΔCRP was 2.1 (0.5-6.2) mg/L in the BMS group and 2.3 (0.2-5.2) mg/L in the DES group, the difference was not statistically significant (p=0.703). ΔCK-MB and adverse cardiac event rates were similar between the two groups (p=0.897 and p=0.785). There was no correlation between ΔCRP and ΔCK-MB (r=-0.090 and p=0.459 for BMS, r=0.158 and p=0.318 for DES). The effect of ΔCRP on the incidence of adverse cardiac events was not significant (p=0.349 for BMS, p=0.135 for DES).


Our findings reveal that patients with BMS and DES implantation exhibit similar grade of systemic inflammation after the procedure. At similar levels of systemic inflammation, the local anti-inflammatory properties of DES can play a role at decreased restenosis rates.

Keywords: Bare Metal Stent, Drug Eluting Stent, CRP, Inflammation

Full Text (Turkish)