Research Article

The Effect of Narrow Band UVB and PUVA Treatment on Serum Folate Levels


  • Seçil Vural
  • Hilayda Karakök Güngör
  • Bengü Nisa Akay
  • Nihal Kundakçı

Received Date: 25.02.2019 Accepted Date: 15.08.2019 J Ankara Univ Fac Med 2019;72(2):205-208


Narrow band UVB (NBUVB) treatment is a preferred dermatological treatment modality especially in pregnant women because of high safety profile. Previous studies have shown photodegradation may decrease folate levels in blood. In this study we aim to investigate if phototherapy causes low folic acid levels in our patients.

Materials and Methods:

Patients applying to dermatology unit and receiving either psoralen plus UVA or NBUVB treatment with regular folic acid level check-ups were analysed retrospectively.


In none of the patients folic acid levels lower than reference levels were detected. Mean serum folate values in baseline were 9.30 (±3.22 SD). The mean value after 18 treatment sessions was 7.26 (±4.82 SD), and after 36 sessions was 8.69 (±3.6 SD). In PUVA group baseline mean folate level was 9.16 (±3.76 SD), followed by 6.76 (±4.89 SD) after 18 sessions and 9.41 (±3.79 SD) after 36 sessions. Repeated measure in time were not statistically significant in both groups (p>0.05).


NBUVB and PUVA treatments appear to be safe in regards to blood folic acid levels in our population where Fitzpatrick skin type III and IV is more common.

Keywords: Narrow Band UVB, Psoralen and UVA, Serum Folate, Pregnant

Full Text (Turkish)