Research Article

The Association Between Whole Blood Viscosity and Obstructive Coronary Artery Disease in Patients with Premature Acute Coronary Syndrome


  • Bahar Tekin Tak
  • Firdevs Ayşenur Ekizler
  • Serkan Çay
  • Habibe Kafes
  • Elif Hande Özcan Çetin
  • Nedret Ülvan
  • Özcan Özeke
  • Fırat Özcan
  • Serkan Topaloğlu
  • Dursun Aras

Received Date: 24.06.2019 Accepted Date: 23.10.2019 J Ankara Univ Fac Med 2019;72(3):307-313


Acute Coronary syndrome (ACS) in young adults is relatively rare, but it is in an increasing trend in recent years. Few data on ACS in young adults are available in the literature, especially regarding risk factors. In the current study, the importance of whole blood viscosity (WBV) was evaluated in patients with newly diagnosed premature ACS.

Materials and Methods:

A total of 713 patients (469 male, mean age: 38.9±2.4 years) were included. The study population was divided into two groups. The first group included 357 patients who presented with newly diagnosed premature ACS (aged ≤45 years and were found to have critical lesions in their coronary arteries, while the control group consisted of 356 patients who were age and gender-matched controls and were found to have normal coronary arteries after elective coronary angiography. WBV was calculated according to the Simone’s formula at both high and low shear rates and compared between two groups with other traditional risk factors.


Patients with premature ACS were found to have significantly increased WBV values compared to controls. Univariate and multivariate logistic regression analysis revealed that the WBV at both shear rates was an independent predictor for the presence of critical CAD after adjusted for other traditional cardiovascular risk factors.


Patients with increased WBV values were at greater risk for the presence of premature ACS with critical lesions compared with the control group.

Keywords: Acute Coronary Syndrome, Shear Rate, Premature, Whole Blood Viscosity

Full Text (Turkish)