Research Article

Epidemiological Analysis of Central Nervous System Teratomas in SEER Database


  • Ercan Bal
  • Recep Öztürk
  • Burak Bahadır
  • Ömer Faruk Türkoğlu
  • Mahmut Nedim Aytekin

Received Date: 09.04.2020 Accepted Date: 21.05.2020 J Ankara Univ Fac Med 2020;73(2):155-159


Teratomas are nongernimmatomatous germ cell tumors of the central nervous system. The aim of this study was to investigate the epidemiological features of central nervous system teratomas.

Materials and Methods:

Central nervous system teratomas were separated according to decades and localization using the United States National Cancer Institute [Surveillance, Epidemiology, and End Results Program (SEER)] database and demographic data were statistically analyzed retrospectively.


Four hundred and twenty-two patients diagnosed with teratoma were found in the SEER database. It was determined that 69% (n=293) of the patients had benign and 31% (n=129) had a malignant histological character. 87.6% (n=113/129) of malignant teratomas were detected in the first two decades. 56.7% (n=166/293) of benign teratomas were found in the first 3 decades of life. Among the lobes of the brain, teratomas are most frequently located in the frontal lobe (9.7%). The rate of teratomas in the pineal region was found to be 16.4%.


Teratomas are frequently seen in the first two decades and approximately two-thirds of all teratomas are benign. While teratomas tend to localize from the brain lobes to the frontal lobe, the most common extra-axial localization is the pineal gland.

Keywords: Germ Cell Tumor, Intracranial Tumor, Pineal Gland, Central Nervous System, Teratoma

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